反应详情

Under a nitrogen purge, 10% platinum on carbon (2.0 grams) was added to a mixture of octadecyl 4-nitrobenzoate (23 grams, 55 mmol) and ethyl acetate (230 milliliters) in a Parr vessel. The vessel was placed under hydrogen pressure (49 psi, 3.3×105 Pa) for sixteen hours. Added chloroform and filtered the reaction mixture through a layer of CELITE filter aid. The filtrate was concentrated under reduced pressure to light tan solid. The solid was recrystallized from ethanol to obtain 18 grams of octadecyl 4-aminobenzoate as a white solid.

1. customUnder a nitrogen purge
2. customfor sixteen hours
3. filtrationAdded chloroform and filtered the reaction mixture through a layer of CELITE
4. filtrationfilter aid
5. concentrationThe filtrate was concentrated under reduced pressure to light tan solid
6. customThe solid was recrystallized from ethanol