HCID 131731598, compound → HCID 131731597, compound

HRID 404379Notes

Reaction equation

HRID 404379 reaction equation
[C:1]([SiH2:5][O:6][C:7]([CH3:30])([CH3:29])[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])=[C:10]([C:23]2([OH:28])[CH2:27][CH:26]=[CH:25][CH2:24]2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CCOC(C)=O.O=[Pt]=O>[C:1]([SiH2:5][O:6][C:7]([CH3:30])([CH3:29])[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])=[C:10]([C:23]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 131731598HCID 131731598, compound

Product 1

HCID 131731597HCID 131731597, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 20.3 (100 mg, 212 μmol) in 2 mL of EtOAc, was added 10% PtO2/C (50 mg). The resulting mixture was stirred under a hydrogen atmosphere for 0.5 hours and then filtered. The filtrate was concentrated to give an oil which was used in the next step.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. customto give an oil which

Sources & evidence

ORD record
ord-0ca89983a95740b0ae7479ada24f7dc8
Source dataset
uspto-grants-2014_06
Patent number
US08748462B2

Reaction notes

Loading…