HCID 24967115, compound → HCID 59290558, compound

HRID 404730Notes

Reaction equation

HRID 404730 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[CH:21]=[N:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.C(O)(C)C>[CH:21]1[C:22]2[C:17](=[CH:16][C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:24][CH:23]=2)[CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 1

HCID 24967115HCID 24967115, compound

Product 1

HCID 59290558HCID 59290558, compoundYield 114.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3776IsopropanolSolvent

Procedure

258 mg (0.79 mmol) 4-(Isoquinolin-6-ylamino)-piperidine-1-carboxylic acid tert-butyl ester were stirred in 6N HCl in isopropanol for 2 h. After evaporation the residue was taken up in water and lyophilized. 206 mg of Isoquinolin-6-yl-piperidin-4-yl-amine as the hydrochloride could be obtained.

Workup

  1. customAfter evaporation the residue

Sources & evidence

ORD record
ord-ddb2fece63054b74bef8a3a2dbadd8be
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

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