Hydrochloric Acid → HCID 68593072, compound

HRID 404749Notes

Reaction equation

HRID 404749 reaction equation
BrC1C=C2C(=CC=1[Cl:12])C=NC=C2.[Cl:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][C:15]=1[S:24][CH2:25][CH:26]1[CH2:30][CH2:29][CH2:28][NH:27]1.C(OC(N1CCCC1CBr)=O)(C)(C)C.Cl>>[ClH:12].[Cl:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][C:15]=1[S:24][CH2:25][CH:26]1[CH2:30][CH2:29][CH2:28][NH:27]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 534186156-Bromo-7-chloroisoquinolineHCID 68593104HCID 68593104, compound

Product 1

HCID 68593072HCID 68593072, compound

Procedure

Starting from 6-Chloro-7-chloroisoquinoline (263) and 2-Bromomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 7-Chloro-6-(pyrrolidin-2-ylmethylsulfanyl)-isoquinoline could be obtained according to the procedures described for 272, 267, 268 as the hydrochloride. Rt=0.85 min (Method B). Detected mass: 279.1/281.2 (M+H+).

Workup

  1. customcould be obtained

Sources & evidence

ORD record
ord-c54819c117db4a4c998b2fdc9bd4ff7e
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

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