反应详情

To a solution of lead(IV)acetate (4.0 g, 0.0089 mol) and mercury(II)acetate (139 mg, 0.45 mmol) in chloroform (12 ml) at 50° C. is added 5-bromo-2-cyclopropylphenyl boronic acid (2.0 g, 0.0083 mol), and the solution is heated at this temperature for 5 hours. After cooling to room temperature the suspension is further cooled to 0° C. and anhydrous potassium carbonate (1.8 g) is added with rapid stirring for 2 minutes. The reaction mixture is then filtered (washing with additional chloroform), and the filtrate is concentrated to half its original volume and the crude product is precipitated with hexanes. Further concentration then filtration affords 5-bromo-2-cyclopropylphenyl lead triacetate as a beige solid.

1. temperaturethe solution is heated at this temperature for 5 hours
2. temperatureis further cooled to 0° C.
3. filtrationThe reaction mixture is then filtered
4. wash(washing with additional chloroform)
5. concentrationthe filtrate is concentrated to half its original volume
6. customthe crude product is precipitated with hexanes
7. concentrationFurther concentration
8. filtrationfiltration