反应详情

Hydroxylamine hydrochloride (385 mg, 5.54 mmol) was added to a solution of sodium bicarbonate (465 mg, 5.54 mmol) in water (17 mL) at room temperature. Then a solution of 2,4-dichloro-5-thiazolecarboxaldehyde (100 g, 5.49 mmol) in ethanol (17 mL) was added The mixture was clear yellow and the precipitates started to appear in ˜20 minutes More water (˜40 mL) was added. After stirring for 1 hour, the reaction was filtered. The solid was washed with water and dried under vacuum overnight to give the title compound as a white sold (883 mg, 82%).

1. filtrationthe reaction was filtered
2. washThe solid was washed with water
3. customdried under vacuum overnight