反应详情

温度

50 °C

To a solution of dodecyne (17.5 mL, 81.7 mmol) in THF (20 mL) in a 250 mL flask equipped with a condenser under an argon atmosphere was added dropwise 36 mL (72 mmol) of a 2 M solution of isopropylmagnesium chloride in THF at room temperature. After addition, the reaction mixture was heated at 50° C. for 95 min and cooled to room temperature. 4,8-Dihydrobenzo[1,2-b:4,5-b′]dithiophene-4,8-dione (3 g, 13.6 mmol) was added, and the mixture was heated at 50° C. for 1 hour before cooling down to room temperature. Subsequently, a solution of 20 g of SnCl2 in 50 mL 10% aqueous HCl solution was added in a dropwise fashion followed by further heating at 60° C. for 1 hour. After the reaction, brine (30 mL) was added. The organic phase was separated and evaporated under vacuum. The residue was diluted with MeOH (100 mL) and filtered. The solid was washed with MeOH several times. The brown solid was purified by column chromatography with CHCl3:hexane 5:6 as eluent. Recrystallization of the crude product collected from flash chromatography from hexane gave 4.03 g (57% yield) of a pale yellow crystal after drying in vacuo. 1H NMR (CDCl3, 500 MHz), δ=7.59 (d, J=5.5 Hz, 2H), 7.51 (d, J=6.0 Hz, 2H), 2.65 (t, J=6.5 Hz, 4H), 1.70-1.80 (m, 4H), 1.56-1.65 (m, 4H), 1.22-1.47 (m, 24H), 0.90 (t, J=6.5 Hz, 6H).

1. additionAfter addition
2. temperaturecooled to room temperature
3. temperaturethe mixture was heated at 50° C. for 1 hour
4. temperaturebefore cooling down to room temperature
5. temperatureby further heating at 60° C. for 1 hour
6. additionwas added
7. customThe organic phase was separated
8. customevaporated under vacuum
9. additionThe residue was diluted with MeOH (100 mL)
10. filtrationfiltered
11. washThe solid was washed with MeOH several times
12. customThe brown solid was purified by column chromatography with CHCl3:hexane 5:6 as eluent
13. customRecrystallization of the crude product
14. customcollected from flash chromatography from hexane