反应详情

温度

90 °C

To 307 mg (2.84 mmol) (2,2-difluorocyclopropyl)methanol in 1,4-dioxane (10 mL) is added 69 mg (2.84 mmol) sodium hydride and 500 mg (2.84 mmol) 2-bromo-6-fluoropyridine. The mixture is stirred for 2 h at 90° C. Water and DMF are added and the mixture is filtered and concentrated in vacuo. The residue is purified by HPLC (C18 RP Sunfire, acetonitrile/water (+0.1% TFA)) to yield the desired product.

1. filtrationthe mixture is filtered
2. concentrationconcentrated in vacuo
3. customThe residue is purified by HPLC (C18 RP Sunfire, acetonitrile/water (+0.1% TFA))