Potassium Carbonate → Ethyl 3-(5-(3-chloro-2-(((2',4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate

HRID 405190Notes

Reaction equation

HRID 405190 reaction equation
Br[C:2]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([Cl:28])[C:3]=1[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[Cl:19])=[CH:8][CH:7]=1.CC1(C)C(C)(C)OB([C:37]2[CH:38]=[CH:39][C:40]([C:43]([NH:45][CH2:46][CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49])=[O:44])=[N:41][CH:42]=2)O1.C([O-])([O-])=O.[K+].[K+]>O1CCOCC1.CCOC(C)=O.[Na+].[Cl-].C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:28][C:20]1[C:3]([CH2:4][NH:5][C:6]2[CH:7]=[CH:8][C:9]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])=[CH:10][CH:11]=2)=[C:2]([C:37]2[CH:38]=[CH:39][C:40]([C:43]([NH:45][CH2:46][CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49])=[O:44])=[N:41][CH:42]=2)[CH:23]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:21]=1

Participants

8

Reactant 3

HCID 11430Potassium CarbonateHCID 71059832Ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoateHCID 86674262N-(2-bromo-6-chloro-4-(trifluoromethyl)benzyl)-2',4'-dichloro-[1,1'-biphenyl]-4-amine

Product 1

HCID 86674264Ethyl 3-(5-(3-chloro-2-(((2',4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate

Reagents, catalysts & solvents 4

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)CatalystHCID 5234Sodium ChlorideSolventHCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

N-(2-bromo-6-chloro-4-(trifluoromethyl)benzyl)-2′,4′-dichloro-[1,1′-biphenyl]-4-amine (4.5 g, 8.8 mmol) and ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate (3.1 g, 8.8 mmol), Pd(dppf)Cl2 (321 mg, 0.4 mmol), and 2 M K2CO3 (aq) (8.8 mL, 17.6 mmol) were dissolved in 1,4-dioxane (35 mL) and heated to 80° C. After 1 h the reaction was cooled to room temperature diluted with EtOAc and 4M aqueous NaCl, and the layers were separated. The aqueous layer was extracted with EtOAc and the combined organics were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

Workup

  1. temperatureAfter 1 h the reaction was cooled to room temperature
  2. customthe layers were separated
  3. extractionThe aqueous layer was extracted with EtOAc
  4. dry with materialthe combined organics were dried (Na2SO4)
  5. concentrationconcentrated
  6. custompurified via column chromatography

Sources & evidence

ORD record
ord-904a29be2f904a329d513cce73f35540
Source dataset
uspto-grants-2014_06
Patent number
US08748624B2

Reaction notes

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