反应详情

tert-Butyl 3-(5-bromopicolinamido)propanoate (3.4 g, 10.3 mmol), (5-chloro-2-formylphenyl)boronic acid (2.1 g, 11.3 mmol), Pd(dppf)Cl2 (840 mg, 1.0 mmol), and K2CO3 (3.1 g, 22.6 mmol) were dissolved in 1,4-dioxane (35 mL) and water (9 mL) and heated to 90° C. After 3 h the resulting mixture was cooled to room temperature, diluted with EtOAc and water and the layers were separated. The combined organics were washed dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. customthe layers were separated
2. washThe combined organics were washed
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. custompurified via column chromatography