反应详情

温度

90 °C

Ethyl 3-(5-bromopicolinamido)propanoate (2.2 g, 7.3 mmol), (5-chloro-2-formylphenyl)boronic acid (1.4 g, 7.7 mmol), Pd(dppf)Cl2 (810 mg, 1.1 mmol), and K2CO3 (2.3 g, 16.9 mmol) and PdCl2(dppf) were dissolved in wet DMF (10 mL) and the resulting mixture was heated to 90° C. After 16 h the resulting mixture was cooled to room temperature, filtered through CELITE and the filtrate was diluted with EtOAc, washed with water and sat. aqueous NaHCO3. The organic layer was dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.

1. temperatureAfter 16 h the resulting mixture was cooled to room temperature
2. filtrationfiltered through CELITE
3. additionthe filtrate was diluted with EtOAc
4. washwashed with water and sat. aqueous NaHCO3
5. dry with materialThe organic layer was dried (Na2SO4)
6. concentrationconcentrated
7. custompurified via column chromatography