反应详情

温度

50 °C

Solid NaBH(OAc)3 (106 mg, 0.50 mmol) was added to a DCE solution (10 mL) of ethyl 3-(5-(3-chloro-5-formylphenyl)picolinamido)propanoate (90 mg, 0.25 mmol), 4′-fluoro-[1,1′-biphenyl]-4-amine (47 g, 0.25 mmol), and AcOH (0.06 mL, 1.00 mmol) and the resulting mixture was heated to 50° C. After 16 h the mixture was concentrated and purified via column chromatography to yield the title compound.

1. concentrationAfter 16 h the mixture was concentrated
2. custompurified via column chromatography