HCID 66863463, compound → HCID 86650195, compound

HRID 405916Notes

Reaction equation

HRID 405916 reaction equation
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:9][CH:10]=[C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 1

HCID 66863463HCID 66863463, compound

Product 1

HCID 86650195HCID 86650195, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

5 g ethyl 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-6-carboxylate and 2.3 g palladium hydroxide are suspended in 180 ml of methanol and hydrogenated at 50 psi for 2 hours at ambient temperature. The catalyst is suction filtered and the mother liquor is evaporated to dryness. 3.6 g (V-2) are obtained as a solid.

Workup

  1. filtrationfiltered
  2. customthe mother liquor is evaporated to dryness
  3. custom3.6 g (V-2) are obtained as a solid

Sources & evidence

ORD record
ord-14b3e489cc1a402db96dbd3af0150787
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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