Acetic Anhydride → HCID 178475036, compound

HRID 406013Notes

Reaction equation

HRID 406013 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].Cl.[F:9][C:10]1[CH:11]=[CH:12][C:13]([N+:24]([O-:26])=[O:25])=[C:14]([CH:23]=1)[O:15][C@H:16]1[CH2:21][CH2:20][C@H:19]([NH2:22])[CH2:18][CH2:17]1.C(N(CC)CC)C.C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl.S([O-])(O)(=O)=O.[K+]>[F:9][C:10]1[CH:11]=[CH:12][C:13]([N+:24]([O-:26])=[O:25])=[C:14]([CH:23]=1)[O:15][C@H:16]1[CH2:17][CH2:18][C@H:19]([NH:22][C:1](=[O:3])[CH3:2])[CH2:20][CH2:21]1

Participants

7

Reactant 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 11430Potassium CarbonateHCID 178479276HCID 178479276, compound

Product 1

HCID 178475036HCID 178475036, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 516920Potassium bisulfateSolvent

Procedure

166 μl acetic anhydride were added to a mixture of 0.341 g trans-4-(5-fluoro-2-nitrophenoxy)-cyclohexylamine hydrochloride and 327 μl triethylamine in 5 ml methylene chloride. The reaction mixture was stirred at rt overnight. The mixture was diluted with methylene chloride and 10% aq. potassium hydrogensulfate and 10% aq.potassium carbonate. Then the mixture was passed through a hydrophobic frit and the solvent was evaporated.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-d259e804a4dd4bad8a0d88ba2c88e9c6
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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