Hydrochloric Acid → HCID 178475043, compound

HRID 406110Notes

Reaction equation

HRID 406110 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:10][CH:9]1[NH:11][C:12]([C:14]1[S:39][C:17]2[N:18]=[CH:19][N:20]=[C:21]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[O:30][C@H:31]3[CH2:34][C@H:33]([NH:35][C:36](=[O:38])[CH3:37])[CH2:32]3)[C:16]=2[C:15]=1[CH3:40])=[O:13])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH:8]1[CH2:10][CH:9]1[NH:11][C:12]([C:14]1[S:39][C:17]2[N:18]=[CH:19][N:20]=[C:21]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[O:30][C@H:31]3[CH2:32][C@H:33]([NH:35][C:36](=[O:38])[CH3:37])[CH2:34]3)[C:16]=2[C:15]=1[CH3:40])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178475044HCID 178475044, compound

Product 1

HCID 178475043HCID 178475043, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 0.15 g [2-({4-[2-(trans-3-acetylamino-cyclobutoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carbonyl}amino)-cyclopropyl]-carbamic acid tert-butyl ester in 5 ml dioxane was added 1 M hydrochloric acid solution in Dioxan and was stirred at rt overnight. The reaction mixture was concentrated and the residue was purified by chromatography.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-326a1e7d6a924e88bb0e75d3596e2c81
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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