Hydrochloric Acid → HCID 58421521, compound

HRID 406111Notes

Reaction equation

HRID 406111 reaction equation
C[O:2][C:3]([C:5]1[S:30][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][C@@H:22]3[CH2:27][CH2:26][CH2:25][CH2:24][C@H:23]3[O:28][CH3:29])[C:7]=2[C:6]=1[CH3:31])=[O:4].[OH-].[Na+].C1COCC1.Cl>O.CO>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:31])=[C:5]([C:3]([OH:4])=[O:2])[S:30][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([O:21][C@@H:22]2[CH2:27][CH2:26][CH2:25][CH2:24][C@H:23]2[O:28][CH3:29])[CH:16]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58421523HCID 58421523, compound

Product 1

HCID 58421521HCID 58421521, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 1.75 g 4-[4-fluoro-2-((1R,2R)-2-methoxy-cyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester, 4M sodium hydroxide solution, 20 ml THF and 20 ml MeOH was stirred at rt overnight. The reaction mixture was acidified by addition of hydrochloric acid, diluted with 80 ml water and filtered. The solid was washed with water and dried in vacuo at 65° C.

Workup

  1. filtrationfiltered
  2. washThe solid was washed with water
  3. customdried in vacuo at 65° C.

Sources & evidence

ORD record
ord-c3da073d481647bb8c695341d31dd7e3
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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