反应详情

2-Phenyl-3-p-tolyl-pyrido[2,3-b]pyrazine (1.07 g, 3.60 mmol) under nitrogen in dry MeOH (10 ml) was treated with ammonium formate (2.269 g, 36.0 mmol) and 10% palladium hydroxide on carbon (200 mg, 0.142 mmol). The resulting mixture was heated at reflux for 1 hour. After cooling to RT, the mixture was filtered through Celite® (filter material) and the catalyst was washed with MeOH followed by DCM. The filtrate was concentrated in vacuo to yield a solid which was triturated with MeOH. The resulting solid was dried under vacuum to afford the title compound;

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 1 hour
3. filtrationthe mixture was filtered through Celite® (filter material)
4. washthe catalyst was washed with MeOH
5. concentrationThe filtrate was concentrated in vacuo
6. customto yield a solid which
7. customwas triturated with MeOH
8. customThe resulting solid was dried under vacuum