Potassium Iodide → HCID 58351061, compound

HRID 406319Notes

Reaction equation

HRID 406319 reaction equation
Cl[CH2:2][C:3](=[O:5])[CH3:4].[Br:6][C:7]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([NH:15][CH:16]=[O:17])=[CH:9][CH:8]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>CN(C)C=O>[Br:6][C:7]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([N:15]([CH2:2][C:3](=[O:5])[CH3:4])[CH:16]=[O:17])=[CH:9][CH:8]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 10796Cesium carbonateHCID 71492501N-(6-bromo-2-methoxypyridin-3-yl)formamide

Product 1

HCID 58351061HCID 58351061, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Chloroacetone (82 mL) was added dropwise to a suspension of N-(6-bromo-2-methoxypyridin-3-yl)formamide (159.3 g), cesium carbonate (359 g) and potassium iodide (11.4 g) in N,N-dimethylformamide (800 mL) over seven minutes. Then, the reaction solution was stirred at room temperature for one hour and 20 minutes.

Sources & evidence

ORD record
ord-c45e7ddb8c2641b0975c3343edd89d1f
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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