Methyl iodide → HCID 58118963, compound

HRID 406439Notes

Reaction equation

HRID 406439 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[N:7]2[CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][CH:13]=3)[CH:10]=[CH:11][C:6]2=[N:5][N:4]=1.[C:25](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH3:25][N:18]([C:15]1[CH:14]=[CH:13][C:12]([C:9]2[CH:10]=[CH:11][C:6]3[N:7]([C:3]([C:2]([F:23])([F:1])[F:24])=[N:4][N:5]=3)[CH:8]=2)=[CH:17][CH:16]=1)[S:19]([CH3:22])(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 58118945HCID 58118945, compound

Product 1

HCID 58118963HCID 58118963, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

N-(4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl)methanesulfonamide (10 mg) was dissolved in DMF (1 mL) and heated with potassium carbonate (39 mg) and methyl iodide (40 mg) for 2 h at 85° C. The reaction mixture was filtered, concentrated, and purified by chromatography using 2% MeOH in methylene chloride as eluent. N-methyl-N-(4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl)methanesulfonamide was obtained as white solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated
  3. custompurified by chromatography

Sources & evidence

ORD record
ord-b955f9c63cb747d1b7a7d67808a2c4ad
Source dataset
uspto-grants-2014_06
Patent number
US08754103B2

Reaction notes

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