反应详情

A mixture of N-(5-formyl-2-methylphenyl)-4-(4-phenylquinazolin-2-ylamino)benzamide (250 mg, 0.546 mmol), cyclopropylamine (238 μL, 3.44 mmol), dichloromethane (10 m:), tetrahydrofuran (2 drops) and acetic acid (2 drops) was stirred at rt for 1 h. Sodium triacetoxyborohydride (275 mg, 1.30 mmol) was added and the mixture was stirred overnight. The crude reaction was diluted with dichloromethane, washed with saturated sodium bicarbonate and saturated sodium chloride and dried over sodium sulfate. The solution was concentrated on a rotary evaporator and purified by HPLC to give a yellow solid (143 mg, 52%).

1. stirringthe mixture was stirred overnight
2. customThe crude reaction
3. washwashed with saturated sodium bicarbonate and saturated sodium chloride
4. dry with materialdried over sodium sulfate
5. concentrationThe solution was concentrated on a rotary evaporator
6. custompurified by HPLC