Hydrochloric Acid → HCID 46234399, compound

HRID 407165Notes

Reaction equation

HRID 407165 reaction equation
[CH3:1][C:2]1[O:3][C:4]([CH3:36])=[CH:5][C:6]=1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([C:20]([C:25]([NH:27][CH2:28][CH2:29][N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)=[O:26])=[N:21][NH:22]3)=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:8].[ClH:37]>O1CCCC1.O1CCOCC1>[ClH:37].[CH3:1][C:2]1[O:3][C:4]([CH3:36])=[CH:5][C:6]=1[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([C:20]([C:25]([NH:27][CH2:28][CH2:29][N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)=[O:26])=[N:21][NH:22]3)=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)=[O:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 46234400HCID 46234400, compound

Product 1

HCID 46234399HCID 46234399, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of 6-(4-(2,5-dimethylfuran-3-carboxamido)phenyl)-N-(2-morpholinoethyl)-1H-indazole-3-carboxamide (38 mg, 78 umol) in tetrahydrofuran (1 Ml), 4N hydrochloric acid solution in dioxane (20 μl) was added at room temperature. After 30 min, the resulting solid was filtered and dried to give 6-(4-(2,5-dimethylfuran-3-carboxamido)phenyl)-N-(2-morpholinoethyl)-1H-indazole-3-carboxamide hydrochloride (35 mg).

Workup

  1. filtrationthe resulting solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-5207bbe70c344d17ae2a2931f534ff3e
Source dataset
uspto-grants-2014_06
Patent number
US08754209B2

Reaction notes

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