Sodium Hydroxide → HCID 86670620, compound

HRID 407183Notes

Reaction equation

HRID 407183 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([C:14]([O:16]CC)=[O:15])[C:6](=[O:13])[N:7]2[C:12]=1[CH:11]=[CH:10][CH:9]=[CH:8]2)=[O:2].[OH-].[Na+:20]>C1COCC1.C(O)C>[CH:1]([C:3]1[CH:4]=[C:5]([C:14]([O-:16])=[O:15])[C:6](=[O:13])[N:7]2[C:12]=1[CH:11]=[CH:10][CH:9]=[CH:8]2)=[O:2].[Na+:20]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 20634151Ethyl 1-formyl-4-oxo-4H-quinolizine-3-carboxylate

Product 1

HCID 86670620HCID 86670620, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethyl 1-formyl-4-oxo-4H-quinolizine-3-carboxylate (see Example 1, 10.1 g, 41.0 mmol) in a mixture of 137 mL of THF and 68 mL of ethanol was added aqueous sodium hydroxide (1N, 43.1 mL, 43.1 mmol). After 4 h, the reaction was concentrated in vacuo to provide sodium 1-formyl-4-oxo-4H-quinolizine-3-carboxylate that gave a mass ion (ES+) of 218.1 for [M+H]+.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-626650367c1f41f3bd975610bc50accd
Source dataset
uspto-grants-2014_06
Patent number
US08754220B2

Reaction notes

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