Phenethylamine → HCID 178434656, compound

HRID 407315Notes

Reaction equation

HRID 407315 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[CH2:21]([NH2:29])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C[N:31]1CCOCC1>CO>[NH2:31][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH2:21][NH:29][S:17]([C:15]2[CH:14]=[CH:13][C:11]3[N:12]=[C:8]([C:3]4[C:4]([CH3:7])=[N:5][NH:6][C:2]=4[NH2:1])[S:9][C:10]=3[CH:16]=2)(=[O:19])=[O:18])=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 1001PhenethylamineHCID 79724-MethylmorpholineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434656HCID 178434656, compoundYield 19.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (25 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), phenethylamine (80 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 429.5 (M+1, 100%). Yield=19%.

Sources & evidence

ORD record
ord-5394ca776b9a4db0a57ceff0c69707f5
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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