4-Methylmorpholine → HCID 178434661, compound

HRID 407316Notes

Reaction equation

HRID 407316 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[N:21]1([CH2:27][CH2:28][NH2:29])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1.CN1CCOCC1>CO>[N:21]1([CH2:27][CH2:28][NH:29][S:17]([C:15]2[CH:14]=[CH:13][C:11]3[N:12]=[C:8]([C:3]4[C:4]([CH3:7])=[N:5][NH:6][C:2]=4[NH2:1])[S:9][C:10]=3[CH:16]=2)(=[O:19])=[O:18])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 4082852-MorpholinoethylamineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434661HCID 178434661, compoundYield 44.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (56 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), 2-morpholin-4-ylethylamine (80 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 423.5 (M+1, 100%). Yield=43%.

Sources & evidence

ORD record
ord-37c32910c9ec482e8ce676f65b4d47ae
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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