4-Methylmorpholine → HCID 178434662, compound

HRID 407323Notes

Reaction equation

HRID 407323 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH2:25].CN1CCOCC1>CO>[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH:25][S:17]([C:15]1[CH:14]=[CH:13][C:11]2[N:12]=[C:8]([C:3]3[C:4]([CH3:7])=[N:5][NH:6][C:2]=3[NH2:1])[S:9][C:10]=2[CH:16]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 66053N,N-DimethylethylenediamineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434662HCID 178434662, compoundYield 9.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (11 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), N1,N1-dimethylethane-1,2-diamine (67 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 381.4 (M+1, 50%). Yield=9%.

Sources & evidence

ORD record
ord-a2862e0fe9c24df1aa93682c5cc01b5d
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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