Methylamine → HCID 178483385, compound

HRID 407341Notes

Reaction equation

HRID 407341 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178509116HCID 178509116, compound

Product 1

HCID 178483385HCID 178483385, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Workup

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Sources & evidence

ORD record
ord-fca9a3df45314300bb3671d7337b2091
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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