Methylamine → HCID 178462848, compound

HRID 40761Notes

Reaction equation

HRID 40761 reaction equation
[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8](Cl)(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12.[CH3:18][NH2:19]>C1COCC1.O>[C:4]1(=[O:12])[N:5]([CH2:6][CH3:7])[C:1](=[O:17])[C:2]2=[CH:16][CH:15]=[CH:14][CH:13]=[C:3]12.[CH3:18][NH:19][SH:8](=[O:9])=[O:10]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 3087392-Phthalimidoethanesulfonyl chloride

Product 1

HCID 178462848HCID 178462848, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

2-Phthalimidoethanesulfonyl chloride (2.0 g) was added portion wise to a solution of 2.0 M methylamine in THF (15 ml) and the solution obtained this way was stirred at room temperature. After 48 hours the reaction mixture was poured in water (50 ml) causing the title compound to precipitate. The product was collected by filtration and recrystallized from EtOH:water, 50:1 to yield: 1.04 g (48%) of the desired product as a solid.

Workup

  1. customthe solution obtained this way

Sources & evidence

ORD record
ord-15af8745e0104771a2b59e6f0ad73bcc
Source dataset
uspto-grants-2013_09
Patent number
US08530486B2

Reaction notes

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