Urea → 5-(Trifluoromethyl)quinazoline-2,4(1H,3H)-dione

HRID 40768Notes

Reaction equation

HRID 40768 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](O)=[O:5].[NH2:15][C:16](N)=[O:17]>>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:8]=[CH:9][CH:10]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:15][C:16](=[O:17])[NH:1]2

Participants

3

Reactant 2

HCID 1176UreaHCID 27785082-Amino-6-(trifluoromethyl)benzoic acid

Product 1

HCID 341761265-(Trifluoromethyl)quinazoline-2,4(1H,3H)-dione

Procedure

Prepared according to general method C from 2-amino-6-trifluoromethylbenzoic acid (1.0 g) and urea (2.92 g). Yield: 948 mg (85%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 11.43 (br s, 2H), 7.78 (t, J=7.9 Hz, 1H), 7.58 (d, J=7.4 Hz, 1H), 7.48 (d, J=8.2 Hz, 1H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-85c7ce1600c24c7a972f69a53beef6cc
Source dataset
uspto-grants-2013_09
Patent number
US08530486B2

Reaction notes

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