反应详情

温度

200 °C

The mixture of the N-(2-ethylphenyl)acetamide (7.35 g, 45.03 mmol), anhydrous K2CO3 (6.22 g, 45.03 mmol), copper(I) bromide (452.2 mg, 3.15 mmol) in 1-bromo-2-ethylbenzene was stirred and heated to 200° C. under argon for 48 h. After cooling the reaction mixture was poured into ice-H2O and extracted with ethyl acetate (2×500 mL), the combined organics were washed with brine, dried over anhydrous (K2CO3), filtered and concentrated to dryness. The crude product was purified using an ISCO machine using a ethyl acetate-hexane gradient to afford the product, N,N-bis(2-ethylphenyl)acetamide (8.1 g, 67%).

1. temperatureAfter cooling the reaction mixture
2. extractionextracted with ethyl acetate (2×500 mL)
3. washthe combined organics were washed with brine
4. dry with materialdried over anhydrous (K2CO3)
5. filtrationfiltered
6. concentrationconcentrated to dryness
7. customThe crude product was purified