反应详情

A mixture of 52.88 g (0.426 mol) of guaiacol (34), 50 ml (0.426 mol) of 1,2-dichloroethane, 88.3 g (0.639 mol) of potassium hydroxide and heated at reflux for 24 h. The mixture was concentrated and extracted into ethyl acetate and evaporate the solvent and purified by column chromatography to gave 41.47 g (52%) of 1-(2-Chloroethoxy)-2-methoxy benzene (35) as a white solid, mp 42-43° C.

1. temperatureheated
2. temperatureat reflux for 24 h
3. concentrationThe mixture was concentrated
4. extractionextracted into ethyl acetate
5. customevaporate the solvent
6. custompurified by column chromatography