反应详情

温度

20 °C

To a solution of 2-bromo-propionic acid ethyl ester (1 eq.) in MeCN was added benzylamine (0.9 eq.) and potassium carbonate (1.5 eq.). The reaction was refluxed for 4 h then cooled to 20° C. and diluted with EtOAc. The crude was filtered, the filtrate was concentrated under reduced pressure, then purified by chromatography on silica gel (elution with heptane/EtOAc: 7/3) to afford 2-benzylamino-propionic acid ethyl ester.

1. temperatureThe reaction was refluxed for 4 h
2. filtrationThe crude was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. custompurified by chromatography on silica gel (elution with heptane/EtOAc: 7/3)