Benzaldehyde → 6-Chloropurine

HRID 408807Notes

Reaction equation

HRID 408807 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](C)[N:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].[CH:11](=O)C1C=CC=CC=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[C:3]=1[NH:10][CH:11]=[N:9]2

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 5941456-Chloro-2-methylpyrimidine-4,5-diamine

Product 1

HCID 53592776-Chloropurine

Procedure

In Step 1, 6-chloro-2-methyl-4,5-pyrimidinediamine is reacted with a benzaldehyde (3) to provide a 6-chloropurine (6), essentially as described in Scheme 1, Step 2, above. In Step 2, a 6-chloropurine (6) is reacted with a piperazine (5) to provide a piperazinyl purine (7) essentially as described in Scheme 1, Step 3, above.

Sources & evidence

ORD record
ord-df9457114dd6437c8f84e6afc3c24f31
Source dataset
uspto-grants-2014_06
Patent number
US08759360B2

Reaction notes

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