反应详情

Heat a solution of 6-chloro-N4-(2-methoxyethyl)-2-methylpyrimidine-4,5-diamine (5.0 g, 0.023 mol), 2-chlorobenzaldehyde (4.8 g, 0.03 mol), 15% FeCl3 on SiO2 (20 g) in 1,4-dioxane (150 mL) to 100° C. for 16 h. Remove the silica by filtration through diatomaceous earth, and concentrate the filtrate under reduced pressure to give a residue. Dissolve the residue in dry dichloromethane (150 mL) and add DDQ (5.2 g, 0.022 mol) at 0° C., and stir the reaction mixture at room temperature for 2 h. Dilute the reaction mixture with dichloromethane, wash with 1 N sodium hydroxide solution, water, and brine. Dry the organic layer over anhydrous sodium sulfate, filter, and concentrate to give a residue. Purify the residue on a silica gel column eluting with ethyl acetate:n-hexane (40:60) to give the title compound (2.9 g). ES/MS m/z 337 (M+1).

1. customRemove the silica
2. filtrationby filtration through diatomaceous earth
3. concentrationconcentrate the filtrate under reduced pressure
4. customto give a residue
5. washwash with 1 N sodium hydroxide solution, water, and brine
6. dry with materialDry the organic layer over anhydrous sodium sulfate
7. filtrationfilter
8. concentrationconcentrate
9. customto give a residue
10. customPurify the residue on a silica gel column
11. washeluting with ethyl acetate:n-hexane (40:60)