Hydrochloric Acid → HCID 67435180, compound

HRID 408821Notes

Reaction equation

HRID 408821 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:29][C:30]([OH:33])([CH3:32])[CH3:31])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([C:24]([O:26][CH3:27])=[O:25])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:28])[N:12]=2>CCOCC>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:29][C:30]([OH:33])([CH3:31])[CH3:32])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([C:24]([O:26][CH3:27])=[O:25])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:28])[N:12]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58459083HCID 58459083, compound

Product 1

HCID 67435180HCID 67435180, compoundYield 161.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Add HCl (2.0 M solution in ether) (0.023 g, 0.0006 mol) to a solution of methyl 4-[8-(2-chlorophenyl)-9-(2-hydroxy-2-methyl-propyl)-2-methyl-purin-6-yl]piperazine-1-carboxylate (0.3 g, 0.0006 mol) in ether (4 mL) at 0° C. and stir for 2 h at room temperature. Filter the precipitate, wash with ether, and dry under vacuum to give the title compound (0.24 g) as a white solid. ES/MS m/z 459 (M+1).

Workup

  1. filtrationFilter the precipitate
  2. washwash with ether
  3. customdry under vacuum

Sources & evidence

ORD record
ord-a7d6da113afd4db6affec058b328344e
Source dataset
uspto-grants-2014_06
Patent number
US08759360B2

Reaction notes

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