反应详情

tert-Butyl 1-piperazinecarboxylate (1.811 g, 9.72 mmol), 2-chloromethyl-thiazole-4-carboxylic acid ethyl ester (2 g, 9.72 mmol), potassium carbonate (2.69 g, 19.45 mmol) and sodium iodide (0.292 g, 1.945 mmol) were combined and stirred in acetonitrile at reflux for 2 hours. The reaction was concentrated under reduced pressure. The residue was taken up in dichloromethane and filtered. The filtrate was concentrated under reduced pressure to give the title compound (4.38 g).

1. temperatureat reflux for 2 hours
2. concentrationThe reaction was concentrated under reduced pressure
3. filtrationfiltered
4. concentrationThe filtrate was concentrated under reduced pressure