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HRID409405

反应详情

EQUATION

反应方程式

HRID 409405 的结构方程式

REACTANTS

反应物

3
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：Nc1ccc2cnccc2c1
HCID588991

6-Aminoisoquinoline

C9H8N2

结构：CC(C)(C)OC(=O)NC(CC(=O)O)c1ccsc1
HCID2764536

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC(CC(=O)Nc1ccc2cnccc2c1)c1ccsc1
HCID59161737

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

To 3-(tert-butyoxcarbonylamino)-3-(thiophen-3-yl)propanoic acid (E4) in pyridine was added EDC, DMAP, and 6-aminoisoquinoline. The solution was stirred for 10 hours at room temperature. The mixture was poured into NaHCO3(sat) and extracted with EtOAc, dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave pure tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-1-(thiophen-3-yl)propylcarbamate (E5).

WORKUP

后处理

  1. extractionextracted with EtOAc
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated