反应详情

To a solution of potassium 4-hydroxy-2,2-dimethylbutyrate (1.92 mmol; 327 mg) in DMF (6 mL) is added ethyl iodide (2.30 mmol; 359 mg). The reaction mixture is stirred for 2 hours, and quenched with saturated ammonium chloride solution. The product is extracted three times with EtOAc. The combined organic layer is washed with aqueous 0.1 M HCl then brine, dried over Na2SO4, filtered, concentrated under reduced pressure to give 4-Hydroxy-2,2-dimethylbutyric acid ethyl ester (520 mg) contaminated with DMF.

1. customquenched with saturated ammonium chloride solution
2. extractionThe product is extracted three times with EtOAc
3. washThe combined organic layer is washed with aqueous 0.1 M HCl
4. dry with materialbrine, dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure