HCID 178506483, compound → HCID 56597374, compound

HRID 409543Notes

Reaction equation

HRID 409543 reaction equation
[O:1]=[C:2]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:16]([C:18]3[N:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]4=[C:20]([C:27]4[CH:28]=[C:29]([CH:38]=[CH:39][CH:40]=4)[C:30]([NH:32]/[C:33](=[N:36]/[H])/[CH2:34]O)=[O:31])[N:19]=3)=[O:17])[CH:8]=2)[NH:3]1>CN(C=O)C.CCOCC>[CH3:34][C:33]1[N:32]=[C:30]([C:29]2[CH:28]=[C:27]([C:20]3[N:19]=[C:18]([C:16]([C:7]4[CH:8]=[C:9]5[C:4](=[CH:5][CH:6]=4)[NH:3][C:2](=[O:1])[N:11]([CH2:12][CH2:13][CH3:14])[C:10]5=[O:15])=[O:17])[N:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=34)[CH:40]=[CH:39][CH:38]=2)[O:31][N:36]=1

Participants

4

Reactant 1

HCID 178506483HCID 178506483, compound

Product 1

HCID 56597374HCID 56597374, compoundYield 86.2%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 0.1 g (0.19 mmol) of 3-{3-[(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazolin-6-yl)carbonyl]imidazo[1,5-a]pyridin-1-yl}-N-[(1E)-hydroxyethanimidoyl]benzamide in 3 ml of DMF is heated at 120° C. for 5 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is taken up in dyethyl ether, filtered, and then dried under reduced pressure at 40° C. overnight. 0.083 g of a yellow solid is obtained.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. filtrationfiltered
  4. customdried under reduced pressure at 40° C. overnight

Sources & evidence

ORD record
ord-6d77a56a10a64eb1b6f1d69921a9fa95
Source dataset
uspto-grants-2014_06
Patent number
US08759344B2

Reaction notes

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