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HRID409587

反应详情

EQUATION

反应方程式

HRID 409587 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：C[C@@H](N[C@H]1CCN(c2ccc(CCS(=O)(=O)CCc3ccc(N4CC[C@H](N[C@H](C)c5cccc6ccccc56)C4)cc3)cc2)C1)c1cccc2ccccc12
HCID67407024

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](N[C@H]1CCN(c2ccc(CCS(=O)(=O)CCc3ccc(N4CC[C@H](N[C@H](C)c5cccc6ccccc56)C4)cc3)cc2)C1)c1cccc2ccccc12.Cl
HCID67409079

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

In a mixed solvent comprising 2 ml of ethyl acetate and 1 ml of chloroform was dissolved 132.5 mg of 4-[(S)-3-[(R)-1-(naphthalen-1-yl)ethylamino]pyrrolidin-1-yl]phenylethylsulfone, 0.8 ml of a solution of 4N hydrogen chloride in dioxane was added thereto, and the precipitated solids were filtered and dried. This was recrystallized from ethanol to obtain 40.0 mg of 4-[(S)-3-[(R)-1-(naphthalen-1-yl)ethylamino]pyrrolidin-1-yl]phenylethylsulfone hydrochloride (the following Table X, Example 12.017).

WORKUP

后处理

  1. additionwas added
  2. filtrationthe precipitated solids were filtered
  3. customdried
  4. customThis was recrystallized from ethanol