Hydrochloric Acid → N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide hydrochloride

HRID 409722Notes

Reaction equation

HRID 409722 reaction equation
[ClH:1].[CH2:2]([NH:4][C:5](=[O:20])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH3:7])[CH3:3]>O1CCOCC1>[ClH:1].[CH2:2]([NH:4][C:5](=[O:20])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH3:7])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86686109N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide

Product 1

HCID 86686110N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide hydrochloride is obtained by adding 4N HCl in dioxane to N-ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide (VI.1). The mixture is stirred for 1 h and the solvent is removed in vacuo. The residue is taken up in diethyl ether, stirred for 20 min and the solvent is evaporated to yield the desired product.

Workup

  1. customthe solvent is removed in vacuo
  2. stirringstirred for 20 min
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-d20590d955b746c6adfe4977379dff94
Source dataset
uspto-grants-2014_06
Patent number
US08759528B2

Reaction notes

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