Trifluoroacetic acid → HCID 18670584, compound

HRID 409728Notes

Reaction equation

HRID 409728 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23][CH3:24])=[O:22])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:24][O:23][C:21](=[O:22])[CH2:20][C:17]1[CH:16]=[CH:15][C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86686116HCID 86686116, compound

Product 1

HCID 18670584HCID 18670584, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound is prepared analogously to Example XI.1 using 4-(4-methoxycarbonylmethyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (VIII.2) as educt and TFA in DCM instead of HCl. The crude product is used without further purification in the next reaction step.

Workup

  1. customThe crude product is used without further purification in the next reaction step

Sources & evidence

ORD record
ord-5ba9e19d331845bebe90e4cae54c84cb
Source dataset
uspto-grants-2014_06
Patent number
US08759528B2

Reaction notes

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