Oxalyl chloride → HCID 59625951, compound

HRID 409913Notes

Reaction equation

HRID 409913 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]2[S:6][C:7]([C:13](O)=[O:14])=[C:8]([C:9]([F:12])([F:11])[F:10])[C:4]=2[CH:3]=1.C(Cl)(C([Cl:22])=O)=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]2[S:6][C:7]([C:13]([Cl:22])=[O:14])=[C:8]([C:9]([F:12])([F:11])[F:10])[C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 591641865-Chloro-3-(trifluoromethyl)-1-benzothiophene-2-carboxylic acid

Product 1

HCID 59625951HCID 59625951, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To compound 18f in CH2Cl2 (5 mL) at room temperature was added (COCl)2, followed by 2 drops of DMF. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 18g.

Workup

  1. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-33489a48cd394b749c728bb541670be1
Source dataset
uspto-grants-2014_06
Patent number
US08759533B2

Reaction notes

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