Trifluoroacetic acid → Trifluoroacetic acid

HRID 409997Notes

Reaction equation

HRID 409997 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH:18]3[CH:14]([N:15](C(OC(C)(C)C)=O)[CH2:16][CH2:17]3)[CH2:13][CH2:12]2)=[O:9])[CH:5]=[N:6][CH:7]=1.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>ClCCl>[CH3:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH:3]=1)[C:8]([NH:10][CH:11]1[CH:18]2[CH:14]([NH:15][CH2:16][CH2:17]2)[CH2:13][CH2:12]1)=[O:9].[C:28]([OH:30])([C:27]([F:32])([F:31])[F:26])=[O:29]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 77442752HCID 77442752, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67369003HCID 67369003, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 50 mL round bottom flask was charged with a magnetic stirbar, Compound 12 (1.5 g, 6.11 mmol) and dichloromethane (25 mL). Trifluoroacetic acid (2.1 g, 18.3 mmol) was added and the reaction mixture was allowed to stir at room temperature for 4 hours. Solvent and volatiles were removed in vacuo overnight to yield Compound 13 as its TFA salt.

Workup

  1. customSolvent and volatiles were removed in vacuo overnight

Sources & evidence

ORD record
ord-a4411e5433c94948a06f1b59d538b6d2
Source dataset
uspto-grants-2014_06
Patent number
US08759539B2

Reaction notes

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