反应详情

Methyl 4-(2-fluorobenzyloxy)benzoate (P1, 10.0 g, 26.9 mmol) was dissolved in methanol (60 mL) and THF (90 mL). A 45 wt % potassium hydroxide solution (20 mL) was then added and the resulting exotherm was controlled by a water bath. After 1.5 days at 20-25° C. the solution became a thick suspension. Using a water bath to control the exotherm, 20 mL of concentrated HCl was added. The mixture was then concentrated to remove the THF and methanol and 150 mL water was added. The solid was isolated by filtration and washed with 50 mL water. After drying under vacuum, the title compound was isolated as a white crystalline solid (9.4 g, 99% yield).

1. customthe resulting exotherm was controlled by a water bath
2. additionwas added
3. concentrationThe mixture was then concentrated
4. customto remove the THF and methanol and 150 mL water
5. additionwas added
6. customThe solid was isolated by filtration
7. washwashed with 50 mL water
8. customAfter drying under vacuum