反应详情

温度

150 °C

A mixture of 2-(4-bromophenyl)-1-(2,4-dihydroxyphenyl)ethanone (5 g, 16.3 mmol) and CuCN (5.8 g, 65.4 mmol) in DMF (50 ml) was stirred at 150° C. for 6 h under nitrogen. Water (100 ml) and EtOAc (100 ml) was added to the mixture. The precipitate was filtered off and the filtrate was washed with brine (100 ml), dried over Na2SO4 and concentrated to give black oil, which was purified by Combiflash (PE/EtOAc=3/1) to afford product as a yellow powder (1.5 g, 36.6%). MS (ESI): m/z 254.1 [M+1]+.

1. filtrationThe precipitate was filtered off
2. washthe filtrate was washed with brine (100 ml)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customto give black oil, which
6. customwas purified by Combiflash (PE/EtOAc=3/1)