Diisopropylcarbodiimide → HCID 178481223, compound

HRID 410109Notes

Reaction equation

HRID 410109 reaction equation
[F:1][C:2]([F:27])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:25])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[O:20][CH2:21][CH:22]([F:24])[F:23])[CH2:5][CH2:4]1.[C:28]([O:32][C:33](=[O:47])[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[C:38]([N:43]=[C:44]=S)[C:37]=1[Cl:46])([CH3:31])([CH3:30])[CH3:29].CC(C)N=C=NC(C)C>>[F:1][C:2]([F:26])([F:27])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([O:20][CH2:21][CH:22]([F:23])[F:24])=[CH:13][C:14]3[N:18]([CH3:19])[C:44]([NH:43][C:38]4[C:39]([Cl:42])=[CH:40][CH:41]=[C:36]([CH2:35][NH:34][C:33]([O:32][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:47])[C:37]=4[Cl:46])=[N:17][C:15]=3[CH:16]=2)=[O:25])[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840196(2,4-Dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl esterHCID 178482270HCID 178482270, compound

Product 1

HCID 178481223HCID 178481223, compound

Procedure

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide and (2,4-dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester with DIC in analogy to examples 7b/7c.

Sources & evidence

ORD record
ord-1d01e2bf72f145c0bfda437023c2ba4f
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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