Diisopropylcarbodiimide → HCID 178425577, compound

HRID 410110Notes

Reaction equation

HRID 410110 reaction equation
[F:1][C:2]([F:27])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:25])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[O:20][CH2:21][CH:22]([F:24])[F:23])[CH2:5][CH2:4]1.[CH3:28][C:29]1[C:42]([N:43]=[C:44]=S)=[C:41]([CH3:46])[CH:40]=[CH:39][C:30]=1[CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35].CC(C)N=C=NC(C)C>>[F:1][C:2]([F:26])([F:27])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([O:20][CH2:21][CH:22]([F:23])[F:24])=[CH:13][C:14]3[N:18]([CH3:19])[C:44]([NH:43][C:42]4[C:41]([CH3:46])=[CH:40][CH:39]=[C:30]([CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35])[C:29]=4[CH3:28])=[N:17][C:15]=3[CH:16]=2)=[O:25])[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840195N-(2,4-Dimethyl-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamideHCID 178482270HCID 178482270, compound

Product 1

HCID 178425577HCID 178425577, compound

Procedure

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide and N-(2,4-dimethyl-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to examples 7b/7c.

Sources & evidence

ORD record
ord-f9498e1f36804d9eae59246354e0570d
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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