反应详情

温度

30 °C

69 g (3 mmol) of sodium were dissolved in 5 l of methanol. Subsequently 425.3 g (3 mol) of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one was added and stirred at 30° C. until a clear solution was obtained. 595 g (3.5 mol) of benzyl bromide was then added and stirred for 1 hour under reflux. The warm, dark colored solution was poured into 15 l of ice water. The product crystallized immediately. The crystals were collected and washed first with 8 l of water and then twice with 2.5 l of ether. The product was left to stand overnight and finally dried at 50° C. for 16 hours. Yield: 646 g.

1. customwas obtained
2. stirringstirred for 1 hour
3. temperatureunder reflux
4. customThe product crystallized immediately
5. customThe crystals were collected
6. washwashed first with 8 l of water
7. waitThe product was left
8. customfinally dried at 50° C. for 16 hours