Methylamine → 3-(Methylamino)-4-nitrobenzoic acid

HRID 410757Notes

Reaction equation

HRID 410757 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14][NH2:15]>C1COCC1>[CH3:14][NH:15][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 5209533-Chloro-4-nitrobenzoic acid

Product 1

HCID 221846233-(Methylamino)-4-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Methylamino-4-nitro-benzoic acid (1.1 g) was prepared by following General Procedure A starting from 3-chloro-4-nitro-benzoic acid (1.0 g) and methylamine (2 M in THF, 8.1 mL) in THF. The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-f69696e8839d43f3a39a54262b77c284
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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