Sodium Methoxide → Methyl 2-methoxy-4-(methylamino)-5-nitrobenzoate

HRID 410784Notes

Reaction equation

HRID 410784 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1F.[CH3:17][O-:18].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[O:18][CH3:17]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 59395139HCID 59395139, compound

Product 1

HCID 67331452Methyl 2-methoxy-4-(methylamino)-5-nitrobenzoateYield 57%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Methoxy-4-methylamino-5-nitro-benzoic acid methyl ester (120 mg) was prepared by following General Procedure A starting from 2-Fluoro-4-methylamino-5-nitro-benzoic acid methyl ester (200 mg) and sodium methoxide (190 mg) in DMF.

Sources & evidence

ORD record
ord-3b6cff1b10a64bd39f4a83177e8c85db
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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